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How does a family history of melanoma impact patients with multiple primary melanomas?
How does a family history of melanoma affect the risk of developing subsequent skin cancers in patients with multiple primary melanomas?
It has been noted that patients with multiple primary melanomas have worse outcomes than those with single primary melanomas.
A study recently published in the Journal of the American Academy of Dermatology investigated how family history of melanoma and germline CDKN2A mutation status of patients with multiple primary melanomas affects their risk of developing subsequent melanomas and other cancers, as well as their survival outcomes.
Using comprehensive data on cancer diagnoses and deaths of patients with multiple primary melanomas and their relatives, the study found that family history and CDKN24 mutation status greatly affects outcomes for these patients.
Familial multiple primary melanoma cases with germline CDKN24 mutations were youngest at the diagnosis of their second melanoma, at an average age of 42 years. This cohort also had the highest relative risk of developing two or more subsequent melanomas.
CDKN24 mutated multiple primary melanoma cases and their first-degree relatives were the only cohorts with increased risks of non-skin cancers. These cohorts also had worse survival outcomes.
The study demonstrated that CDKN24 mutation status and family history of melanoma significantly affects outcomes of patients with multiple primary melanomas.
Helgadottir, H. et al. (November 2017.) Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status. Journal of the American Academy of Dermatology. Volume 77, Issue 5, Pages 893-901. DOI: http://dx.doi.org/10.1016/j.jaad.2017.05.050.
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