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BRAF Mutation Associated With Central Nervous System Metastasis in Melanoma Patients
BRAF mutation is associated with sentinel lymph node positivity and central nervous system metastasis in patients with primary cutaneous melanoma, according to new research.
The findings were presented at the 9th World Congress of Melanoma and 14th International Congress of the Society for Melanoma Research.
A cohort of 1,544 patients with primary cutaneous melanoma were analysed to determine whether BRAF-mutant, NRAS-mutant and wild-type tumours differ in their sites of visceral metastasis.
Patients were followed over an average of 4.6 years. Of the 1,544 patients, 234 developed distant metastatic disease. Nearly 41 percent of tumours were BRAF-mutant and over 18 percent were NRAS-mutant.
BRAF mutation was associated with a greater risk of central nervous system metastases. The evidence also indicated that BRAF mutation might be associated with the development of liver metastasis. No association was observed between BRAF mutation and lung metastasis.
The evidence was uncertain as to an association between NRAS mutation and central nervous system or liver metastases.
Of 629 patients who underwent sentinel lymph node biopsy, 169 (27 percent) were positive. BRAF mutation was associated with sentinel lymph node biopsy positivity and worse melanoma-specific survival.
NRAS mutation did not appear to be associated with sentinel lymph node biopsy positivity; however, patients with NRAS-mutant melanomas had worse melanoma-specific survival.
The researchers therefore concluded that BRAF mutation is associated with sentinel lymph node positivity and central nervous system metastasis. They recommended that, if this finding is validated in additional prospective studies, a role for heightened central nervous system surveillance may be warranted in patients with BRAF-mutant tumours. Further, while NRAS mutation was not associated with sentinel lymph node biopsy, it was associated with poorer survival in patients with cutaneous melanoma.
Adler, N.R, et al. (October 2017.) BRAF mutation is associated with sentinel lymph node positivity and central nervous system metastasis in patients with primary cutaneous melanoma. 9th World Congress of Melanoma and 14th International Congress of the Society for Melanoma Research. Retrieved from: http://www.professionalabstracts.com/melanoma2017/Iplanner/#/presentation/314
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